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VATSADZE Sergey

PhD, Dr Habilitat, Professor of the Russian Academy of Sciences

Head, Laboratory of Supramolecular Chemistry, Zelinsky Institute of Organic Chemistry, RAS (ZIOC RAS)

 

Address: 119991, Russian Federation, Moscow, Leninsky Pr., 47,

ZIOC RAS, off. 402

 

Phones:

cell +7-903-7487892

work +7 (499) 137-2944

 

E-mail:

zurabych@gmail.com

vatsadze@ioc.ac.ru

Head, Laboratory of Supramolecular Chemistry, Zelinsky Institute of Organic Chemistry, RAS (since 2020)

Professor of Organic Chemistry, the Department of Chemistry, Lomonosov Moscow State University (since 2012)

Professor of Organic Chemistry, Mendeleev University of Chemical Technology (since 2021)

Advisor to the Dean, the Department of Chemistry, Lomonosov Moscow State University (since 2020).

 

Academic titles

Professor of the Russian Academy of Sciences (2016)

Professor in Organic Chemistry (2011)

 

Doctoral dissertation (Habilitation, 2008): «Polydentate organic and complex ligands in the design and synthesis of supramolecular architectures»

Papers (since 1989) 163. Patents (since 2015) 6. Presentations at conferences (since 1994) more than 170, including 41 plenary, keynote and invited talks for the last 5 years.

H-index — 21 (Scopus); citations (Scopus) 2252

 

Main achievements during last 5 years

The concept of “stereoelectronic chameleons” which explains the difference of reactivity of common functional groups depending on their mutual spatial orientation was introduced.

Bispidine-ferrocene macrocycles representing a new class of macro-hetero-metallacycles were synthesized and fully characterized.

Bispidines were shown as promising inhibitors of SARS-CoV-II main protease.

New ligands for lanthanide luminescent complexes were designed with the aim to increase the efficiency of OLED devises.

Supramolecular gels and metallogels were synthesized and studied as potential catalytic systems.

Bispidine-terpene conjugates were suggested as components of catalytic systems for many important organic reactions, including: Henry reaction, Michael reaction, addition of diethyl zinc to aldehydes and chalcones, addition of acetylenes to aldehydes.

The concept of labeled catalyst which helps to study the details of organic reaction mechanisms was introduced.

Cross-conjugated dienones were introduced as components of supramolecular photoactive devises.

 

The main areas of activity of the Laboratory of Supramolecular Chemistry of ZIOC RAS are research activities in the field of supramolecular chemistry, namely, design, synthesis and study of new molecules as components of functional supramolecular assemblies and materials based on them, as well as application of supramolecular approaches in organic chemistry, medicinal chemistry and organic materials science, including:

— Synthesis of polyhedentate polyheterocyclic compounds, including chiral macrocyclic and macropolycyclic compounds, as selective receptors and catalysts;

— A detailed study of the interaction of synthetic and natural molecules with natural and synthetic receptors by experimental and theoretical methods;

— Study of the principal role of weak interactions as applied to study the mechanisms of organic reactions including the study of stereoelectronic effects by computational and experimental methods;

— Development of systems for selective delivery and controlled release of drugs and agrochemicals based on complexes of inclusion of active molecules in the cavities of macrocyclic receptors;

— Creation of means for bioimaging with the help of lanthanide complexes and luminescent organic molecules and photophysical materials based on them;

— Synthesis and study of supramolecular polymers, including gels and metallogels, metal-organic frameworks, supramolecular organic frameworks, covalent organic frameworks; study of photochemical, sorption, catalytic, magnetic properties of the obtained new materials.

 

We should also note the extensive opportunities of the laboratory for domestic and international collaborations. In particular, the team has stable connections and fruitful cooperation with colleagues from Lomonosov Moscow State University (Moscow), Vorozhtsov Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences (SB RAS, Novosibirsk, Russia), Boreskov Institute of Catalysis, SB RAS (Novosibirsk), Razuvaev Institute of Organometallic Chemistry of RAS (Nizhny Novgorod), Kurnakov Institute of General and Inorganic Chemistry of RAS (Moscow), Photochemistry Center of RAS (Moscow), Arbuzov Institute of Organic and Physical Chemistry of RAS (Kazan), Favorsky Institute of Chemistry of SB RAS (Irkutsk), St. Petersburg State University (St. Petersburg), Tomsk Polytechnic University (Tomsk), Florida State University (USA; Prof. Igor Alabugin), Zhejiang University (China; Prof. Wang Li, Prof. Yu Haojie), Tsinghua University (China; Prof. Wang Mei-Xiang).

Vatsadze Sergey’s main works (2022-2026):

  1. Vatsadze S. Z., Sinyashin O. G., Zakharova L. Ya. et al «Amphiphilic 1-alkyl-1,3-diazaadamantan-1-azonia bromides: A journey into self-organization and interaction with the lipid bilayer» //Journal of Molecular Structure. 2026. Vol. 1351. 144157.
  2. Prima D. O., Vatsadze S. Z. «Cocktail-type Catalysis – An Emerging Concept in Metal-Mediated Transformations» // Organometallics. 2025. Vol. 44. No. 13. P. 1337–1357. (Review).
  3. Wang L., Yu. H., Vatsadze S. Z. et al «The pH-responsive microneedles based on dynamic phenyl borate ester bonds and electrostatic interaction for the treatment of gouty arthritis» // Applied Materials Today. 2025. Vol. 47. 102980.
  4. Vatsadze S. Z., Shevelkov A. V. et al «A new supramolecular tecton: the crucial impact of the polycation charge and geometry of H-bonds on the structure and properties of halometallates in the solid state» // Dalton Transactions. 2025. Vol. 54. No. 17. P. 6983-6992.
  5. Vatsadze S. Z., Fedorov A. Yu. et al «Developing Chlorin/Arylaminoquinazoline Conjugates with Nanomolar Activity for Targeted Photodynamic Therapy: Design, Synthesis, SAR, and Biological Evaluation” // Journal of Medicinal Chemistry. 2025. Vol. 68. No. 2. P. 1901–1923.
  6. Vatsadze S. Z., Kalmykov S. N., Beloglazkina E. K. et al “Synthesis of bispidine based PSMA targeted conjugate and initial investigations” // Organics. 2025. Vol. 6. No. 1. P. 7-23.
  7. Medved’ko A. V., Vatsadze S. Z. et al «Cycloruthenated thiophene-imines: novel anticancer agents» // Journal of Organometallic Chemistry. 2025. V. 1038. 123726.
  8. Vatsadze S. Z., Prikhodchenko P. V. et al “Dioxygen–halogen bonding exemplified by crystalline peroxosolvates of N , N ′-bis(haloacetyl) bispidines” // Physical Chemistry Chemical Physics. 2024. Vol. 26. 5195-5206.
  9. Vatsadze S. Z., Fedorov A. Yu. et al “A first-in-class β-glucuronidase responsive conjugate for selective dual targeted and photodynamic therapy of bladder cancer” // European Journal of Medicinal Chemistry. 2024. Vol. 269. 116283.
  10. Medved’ko A. V., Vatsadze S. Z. et al “Synthesis of N,N′-unsymmetrical 9-amino-5,7-dimethyl-bispidines” // The Journal of Organic Chemistry. 2023. Vol. 88. 7272-7280.
  11. Almir S. Gazizov, Andrey V. Smolobochkin, Tanzilya S. Rizbayeva, Sergey Z. Vatsadze, Alexander R. Burilov, Oleg G. Sinyashin, Igor V. Alabugin ““Stereoelectronic deprotection of nitrogen”: recovering nucleophilicity with a conformational change” // The Journal of Organic Chemistry. 2023. Vol. 88. 6868-6877.
  12. Vatsadze S. Z., Veselova I. A. et al «Plier Ligands for Trapping Neurotransmitters into Complexes for Sensitive Analysis by SERS Spectroscopy» // Biosensors. 2023. Vol. 13. 124.
  13. Medved’ko A. V., Vatsadze S. Z. et al «Bispidine-Based Macrocycles: Achievements and Perspectives» // Organics. 2023. Vol. 4. 417-437 (Review).
  14. Vatsadze S. Z., Wang M.-X. et al “C1-symmetric aza-crown ethers as chiral shift agents for amines and amino acid derivatives” // Tetrahedron. 2023. Vol. 131. 133207.
  15. Vatsadze S. Z., Utochnikova V. V. et al “NIR-emitting ytterbium complexes with a large Stokes shift for detection of sulfide” // Journal of Luminescence. 2023. Vol. 263. 120054.
  16. Vatsadze S. Z., Maximov А. L., Bukhtiyarov V. I. «Supramolecular effects and systems in catalysis» // Doklady Chemistry. 2022. Vol. 502. №1. 3-31 (Review).
  17. Yarovaya O. A., Salakhutdinov N. F., Vatsadze S. Z. et al “Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors” // ACS Medicinal Chemistry Letters. 2022. Vol. 13(1). 140-147.
  18. Suslov E. V., Vatsadze S. Z. et al “Bispidine Platform as a Tool for Studying Amide Configuration Stability” // Molecules. 2022. Vol. 27(2). 230.
  19. Vatsadze S. Z., Utochnikova V. V. et al «Ytterbium complexes with 2-tosylamino-4-bromobenzylidene-halogenbenzoyhydrazones for highly NIR emitting solution-processed OLEDs» // Journal of Luminescence. 2022. Vol. 244. 118702.
  20. Fomina M. V., Vatsadze S. Z., Gromov S.P. et al «Structure-Property relationships of Dibenzylidenecyclohexanones» // ACS Omega. 2022. Vol. 7(12). 10087-10099.